The clinical significance of the Alter G Anti-Gravity Treadmill is enabled by manipulating differential air pressure; creating a pressurised lifting force to decrease the impact of gravitational forces and body weight during locomotion. As a result, ground reaction forces are minimised and the associated muscles work at a safer, less strenuous level to attenuate forces. Alongside smaller ground reaction forces, the gravitational load can be reduced from 100% to as low as 20% of body weight, allowing us to target biomechanical insufficiencies and maintain cardiovascular fitness without overloading the patient specific site of injury. As such, the Anti-Gravity Treadmill appeals to any individual whose lower extremity symptoms are related to full weight bearing during ambulation or exercise.